As arteriosclerosis advances, it may occlude a coronary vessel, and cut off oxygen supply to heart muscle. The pump weakens, and delivers less oxygen to organs. The outcome of this emergency depends on how WOB and rescue team will handle oxygen shortage. Even before their arrival WOB cuts oxygen from unnecessary functions, diverting it to the more needy, like brain and kidney, and if shortage is extreme, you faint. Lack of oxygen threatens to destroy heart muscle that was nourished by the occluded artery and can be ameliorated by cutting down oxygen utilization. Applying the stream metaphor, upper stream is oxygen supply, lower stream is utilization, and oxygen pool is tolerance. WOB puts parts of the affected heart muscle to sleep (hibernating myocardium). Muscle utilizes less oxygen (cutting down the lower stream), keeping the rest to maintain its essential functions and survive.
Oxygen shortage continues. Organs cut down their metabolism, and if this not enough, WOB continues cutting off blood supply even to vital organs like kidney. All resources are diverted to keep the brain alive. When oxygen is too low. Certain brain functions are turned off, and the patient sinks in coma, when only the most essential functions like heart rate and breathing are maintained. Coma is WOB' s answer to extreme oxygen shortage. Each of the different states, infarction, fainting, and coma, are WOB' s attempts to stabilize tolerance. If succeeding it will prevail in a given state and mobilize healing resources. Now the outcome depends on your reserves (tolerance). If you have been exercising, WOB grew new blood vessels that carried additional blood to affected heart muscle. These vessels will assist you during emergency.
Exercise generally does not prevent heart attacks, it only determines their outcome. And so does WOB boosting in cancer.
Myocardial infarction is a systemic disease. The acute event seems to be localized in the heart, yet the entire process following it is systemic. So is cancer. It seems to be localized in the tumor, yet the entire process following it is systemic.