New Frontiers in Cancer Causation.
OH Iversen, Editor p. 81-107
Taylor & Francis, Washington DC, 1993.
This article has been revised. Some sections appear under
different headings and the reader is advised to start with the following chapters::
According to the current
dogma cancer is a parasite originating in a chance event, transforming a healthy
cell into a fierce crab, proliferating without restraint until destroying its
host. In spite of its simplicity, this guiding principle fails to cure most
patients. Treatment fails since it is based on false premises. It is presumed
here that the necessary information for understanding cancer is known and is
Cancer is a metabolic deficiency, that starts with stem cell depletion.
Stem cells secrete a substance 'A' that is essential for the maintenance
of transitional cells. Since in the adult stem cell replenishment
is sluggish, the organism activates a salvation process in form of the neoplasm
for replenishing the loss. and restores the reversible deficiency.
With time deficiency gets worse. In order to make up for the loss
the tumor has to grow more and more, causing pain and secondary damage to vital
functions. Cancer is viewed here as pernicious cachexia induced by the
loss of a vital metabolite produced by stem cells and compensated by neoplasia.
Two factors determine the intensity of the 'A' deficiency,
stem cell depletion and its uptake rate by transitional cells. Carcinogens
initiate stem cell depletion, while anti-carcinogens restore it. Promoters increase
'A' uptake by transitional cells and anti-promoters decrease it. Stem cells
are depleted also by a carcinogen induced neuropathy.
Diseases, e.g., Hodgkin's disease, seminoma, connective tissue sarcoma
start as inflammations that become malignant. Chemotherapy
is effective only during their inflammatory phase. The favorable response of
childhood cancer to therapy results from the capability of the growing organism
to replenish lost stem cells.
1 The failure of the current dogma
According to the current dogma cancer is a parasite originating in a chance
event, transforming a healthy cell into a fierce crab, proliferating without
restraint until destroying its host . This parasite should obviously be eliminated
as soon as possible. And yet in spite of its simplicity, this guiding principle
fails to cure most patients.
2 Cancer starts as a systemic illness
Oncology maintains that neoplasia is the primary factor in cancer, and
that para-neoplasia and cachexia are secondary. Here it is proposed that cancer
is first of all a cachexia initiated by para-neoplasia and compensated
3 The example of pernicious anemia
Cancer is viewed here as pernicious cachexia induced by the loss of a vital
metabolite that is secreted by stem cells and compensated by neoplasia.
4 Streaming organism
The organism is composed of myriads of cell streams that maintain homeo-rhesis.
Each stream represents one tissue unit that is nourished by a determined
5 Unit hypertrophy and hyperplasia
Tissue units may enlarge by accumulating transitional cells, and when losing
them they shrink. The two conditions are called respectively hypertrophy
and atrophy (or hypotrophy). Unit hyperplasia occurs when entire units
multiply , e.g., during growth.
6 The adult organism is incapable of increasing its stem cell pool.
While a growing child is capable of creating new tissue units, and replenishing
lost units with new ones. In the adult this facility is either lost, or
extremely reduced .
7 Cancer starts with stem cell depletion
The postulated metabolic deficiency of cancer starts with stem cell
depletion. Any agent that destroys stem cells is a carcinogen. Stem cells secrete a substance 'A' that is essential
for the maintenance of transitional cells. When in the adult, stem cells are
lost the organism activates a salvation strategy in form of a
neoplasm that secretes a substitute called 'B'.
8 Deficiency promotion
Agents that increase 'A' uptake by transitional cells are called promoters.
Any agent the diminishes uptake of the stem cell metabolite by transitional
cells is an anti-promoter.
10 The main beneficial effect of chemotherapy is due to anti-promotion.
When the patient is first treated, chemotherpy reduces its proliferating
transitional cells (anti-promotion) and the deficiency is ameliorated.
Yet since chemotherapy depletes also stem cells (carcinogenesis), the
relief is brief. Deficiency deepens and the neoplasm enlarges. Anti-promotion
is also the main benefit of adjuvant chemotherapy in breast cancer.
Any agent that increases the stem cell pool is anti-carcinogenic, e.g., unit
hyperplasia during organ growth. Most childhood cancers are actually
congenital malformations induced by teratogens. Generally teratogens
cause malformations yet when depleting also stem cells, malformations are
accompanied by cancer.
12 Congenital neoplasia
The younger a child that carries a neoplasm the better its chances to
be cured since its capacity to form new units (or anti-carcinogenic
potential) is the greatest.
13 Trophic effect of neurons
The nervous system modulates the metabolism of all organs in the body as well
as their stem cells. . This trophic effect is poisoned by carcinogens
that initiate the 'A' deficiency and cancer.
14 Cancer as a neural disease
Carcinogen induced neuropathy initiates cancer by stem cell depletion and
is clinically manifested as para-neoplasia.
15 Cancer treatment
Carcinogen prevention is the best cancer treatment. Then comes replacement
of the missing 'A' or its 'B' substances. Finally, anti-promotion. Even cachexia
has some beneficial aspects, since acting as anti-promoter.
16 Carcinogenesis by organ resection.
Gastric surgery for benign conditions is accompanied by an increased tendency
to get gastric stump carcinoma. Partial colon resection promotes cancer growth
in rats. Partial hepatectomy accelerates hepato-carcinogenesis. Since
removing stem cells these procedures are carcinogens.
17 Inflammatory cancers
At least some esoteric cancers, e.g., Hodgkin's disease, seminoma, osteosarcoma,
childhood leukemia, yield to massive irradiation or chemotherapy. Yet
resistance to chemotherapy is pathognomonic of cancer, so that
if a tumor yields to chemotherapy it is non cancerous.
18 Hodgkin's disease
Starts as chronic inflammation (granuloma) and ends as lymphoma. Chemotherapy
is effective only in the first stage.
Most seminomas exhibit a clear inflammatory component, e.g., lymphocytic
infiltration and granulomatous reaction. It appears as if seminoma, Hodgkin's
disease, osteosarcoma and connective tissue sarcomas, start as inflammatory
diseases and only later turn into malignancies. The dramatic response to therapy
of childhood cancers and leukemia is ascribed here to the anti-carcinogenic
potential of the growing organism.
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